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发布时间：2023-08-30 16:03 咨询量：
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产品详情
| 名称 ： | anti- Chk2 antibody |
|---|---|
| 货号： | FNab01654 |
| 适应种属： | 人源,大鼠,小鼠 |
| 规格： | 100ug(微克) |
| 状态： | 液体 |
| 纯化方法 ： | 免疫亲和纯化 |
| 纯度 ： | 经SDS-PAGE分析,纯度大于95% |
| 宿主： | 兔 |
| 亚型 ： | lgG |
| 存储 ： | 用添加了0.02%叠氮化钠和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12个月（避免反复冻融） |
| 免疫原： | CHK2 checkpoint homolog (S. pombe) |
| 分子量 ： | 70 kDa |
| 验证应用： | ELISA, WB, IHC, IF |
| 建议稀释比例： | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 |
| UniProt ID ： | O96017 |
| 克隆性： | 多克隆 |
| 背景介绍： | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarc |
| 图像 ： |  Immunofluorescence analysis of A549 cells using FNab01654(Chk2 antibody) at dilution of 1:100。
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