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产品详情
| 名称 ： | anti- Chk1 antibody |
|---|---|
| 货号： | FNab01652 |
| 适应种属： | 人源,大鼠,小鼠 |
| 规格： | 100ug(微克) |
| 状态： | 液体 |
| 纯化方法 ： | 免疫亲和纯化 |
| 纯度 ： | 经SDS-PAGE分析,纯度大于95% |
| 宿主 ： | 兔 |
| 亚型 ： | lgG |
| 存储： | 用添加了0.02%叠氮化钠和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12个月（避免反复冻融） |
| 免疫原 ： | CHK1 checkpoint homolog (S. pombe) |
| 分子量： | 54 kDa |
| 验证应用 ： | ELISA, WB, IHC |
| 建议稀释比例： | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| UniProt ID ： | O14757 |
| 克隆性： | 多克隆 |
| 背景介绍： | The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. |
| 图像： |  Immunohistochemistry of paraffin-embedded human gastric cancer using FNab01652(Chk1 antibody) at dilution of 1:100。
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