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产品详情
| 名称： | anti- RAB8A antibody |
|---|---|
| 货号 ： | FNab07045 |
| 适应种属： | 人源,大鼠,小鼠 |
| 规格 ： | 100ug(微克) |
| 状态： | 液体 |
| 纯化方法： | 免疫亲和纯化 |
| 纯度： | 经SDS-PAGE分析,纯度大于95% |
| 宿主 ： | 兔 |
| 亚型： | lgG |
| 存储 ： | 用添加了0.02%叠氮化钠和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12个月（避免反复冻融） |
| 免疫原： | RAB8A, member RAS oncogene family |
| 免疫原别称 ： | MEL antibody, Oncogene c mel antibody, RAB8 antibody, RAB8A antibody, Ras related protein Rab 8A antibody |
| 分子量： | 24 kDa |
| 验证应用： | ELISA, WB, IF, IP |
| 建议稀释比例 ： | WB: 1:500-1:5000; IP: 1:200-1:2000; IF: 1:10-1:100 |
| UniProt ID ： | P61006 |
| 克隆性： | 多克隆 |
| 背景介绍 ： | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites(AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose |
| 图像： |  IP Result of anti-RAB8A (IP:FNab07045, 3ug; Detection:FNab07045 1:500) with HeLa cells lysate 2500ug。
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