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      发布时间 :2024-02-04 15:52   咨询量:
    1. 英文名称:anti- E-cadherin antibody
    2. 产品货号 : FNab02618
    3. 适应种属:人源,大鼠,小鼠
    4. 宿主:兔
    5. 亚型:lgG
    6. 验证应用 : ELISA, IHC, WB
    7. 简介:js3333线路检测中心生物抗E-cadherin抗体经SDS-PAGE分析 ,纯度大于95%,采用免疫亲和纯化方法,为用户提供高亲和力 、高特异性的优质抗体 。
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      产品详情
      名称:anti- E-cadherin antibody
      货号 : FNab02618
      适应种属:人源,大鼠,小鼠
      规格:100ug(微克)
      状态:液体
      纯化方法:免疫亲和纯化
      纯度 :经SDS-PAGE分析,纯度大于95%
      宿主:
      亚型:lgG
      存储:用添加了0.02%叠氮化钠和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12个月(避免反复冻融)
      免疫原: cadherin 1, type 1, E-cadherin (epithelial)
      免疫原别称: Arc 1 antibody, Cadherin 1 antibody, CD324 antibody, CDH1 antibody, CDHE antibody, E cadherin antibody, ECAD antibody, E-cadherin antibody, LCAM antibody, UVO antibody, Uvomorulin antibody
      分子量: 130 kDa
      验证应用: ELISA, IHC, WB
      建议稀释比例: WB: 1:500 - 1:1000; IHC: 1:50 - 1:200
      UniProt ID: P12830
      克隆性 :多克隆
      背景介绍 :This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
      图像  :E-cadherin抗体
      Immunofluorescent analysis of (10% Formaldehyde ) fixed A431 cells using FNab02618 (E-cadherin Antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)。
      anti- E-cadherin antibody
      Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab02618( E-cadherin Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9)。
      E-cadherin抗体
      mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab02618(E-cadherin antibody) at dilution of 1:1000 。
      

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